Selenium nanoparticles reduce oxidative stress-induced cardiomyocyte apoptosis in ascites syndrome in broiler chickens via the ATF6-DR5 signaling pathway

Abstract Broiler ascites syndrome (AS) is one of the main diseases threatening health broilers. It well documented that myocardial hypertrophy and failure key mechanisms broiler syndrome. Therefore, prevention cardiac would be goal to reduce incidence. Myocardial are closely related endoplasmic reticulum stress (ERS) in myocytes, signaling system (ATF6-DR5) important pathways apoptosis. Excessive will affect heart muscle’s normal contraction diastole function, turn from compensated decompensate thus causing injury. apoptosis a core component pathological changes this Nano-selenium kind red elemental selenium nanoparticle. Due its excellent physical, chemical biological properties, it has attracted extensive academic attention recent years. been proven have antioxidant, antibacterial, antitumor, antihypertrophic, antiapoptotic abilities. Herein, nano-selenium (1 µmol/L) can inhibit hydrogen peroxide (H 2 O )-induced oxidative primary cardiomyocytes, at same time cardiomyocyte In vivo , injury-related enzyme indicators (AST, CK LDH), alleviate also activate antioxidant (SOD, GSH-Px CAT) MDA, make recovery T-AOC ability organization. Meanwhile, down-regulate genes proteins expression ATF-6, GRP-78, CHOP caspase 12 ERS-related pathway, downstream-related 3, Bax 9, increase downstream anti-apoptotic Bcl-2, thereby maintaining homeostasis alleviating seen protect damaged myocardium caused by high-salt drinking regulating ATF6-DR5 pathway. This study was performed chickens cells attempted demonstrate nanoparticles ascites. paper provides new idea for preventing treating